Original Papers Aiming Glioma Therapy


1) Sakai H, Nakashima S, Yoshimura S, Nakatani K, Shinoda J, Sakai N, Yamada H, Nozawa Y: Suppressed expression of CD44 variant isoforms during human glioma A172 cell differentiation induced by cyclic AMP. Neurosci. Lett., 210; 189-192 (1996)

2) Yoshimura S, Sakai H, Nakashima S, Nozawa Y, Shinoda J, Sakai N, Yamada H: Differential expression of rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation. Mol. Brain Res., 45; 90-98 (1997)

3) Yoshimura Y, Sakai H, Ohguchi K, Nakashima S, Banno Y, Nishimura Y, Sakai N, Nozawa, Y: Changes in the activity and mRNA levels of phospholipase D during ceramide-induced apoptosis in rat C6 glial cells. J. Neurochem., 69; 713-720 (1997)

4) Sakai H, Nakashima S, Yoshimura S, Nishimura Y, Sakai N, Nozawa Y: Identification of differentially expressed mRNAs during rat C6 glioma cell differentiation by mRNA fingerprinting using arbitrarily primed PCR (RAP). Neurosci. Lett., 229; 93-96 (1997)

5) Sakai H, Nakashima S, Nakatani K, Yoshimura S, Nishimura Y, Sakai N, Nozawa Y: Messenger RNA fingerprinting analysis using arbitrarily primed PCR (RAP) of genes expressed during rat C6 glioma cell differentiation. Brain Tumor Pathol., 14, 119-123 (1997)

6) Sakai H, Nakashima S, Yoshimura S, Nishimura Y, Sakai N, Nozawa Y: Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation. Gene, 209; 87-94 (1998)

7) Sawada M, Nakashima S, Banno Y, Yamakawa H, Takenaka K, Shinoda J, Nishimura Y, Sakai N, Nozawa Y: Influence of Bax or Bcl-2 overexpression on the ceramide-dependnet apoptotic pathway in glioma cells. Oncogene 19, 3508-3520 (2000)

8) Sawada M, Nakashima S, Banno Y, Yamakawa H, Hayashi K, Takenaka K, Nishimura Y, Sakai N, Nozawa Y: Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apotosis in C6 glioma cells. Cell Death Differ., 7; 761-772 (2000)

9) Sawada M, Nakashima S, Kiyono T, Nakagawa M, Yamada J, Yamakawa H, Banno Y, Shinoda J, Nishimura Y, Nozawa Y, Sakai N: p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells. Oncogene, 20,1368-1378 (2001)

10 ) Noda S, Yoshimura S, Sawada M, Nakagawa T, Iwama T, Nakashima S, Sakai N: Role of ceramide during cisplatin-induced apoptosis in C6 cells. J. NeuroOncol., 52; 11-21 (2001)

11) Sawada M, Nakashima S, Kiyono T, Yamada J, Hara S, Nakagawa M, Shinoda J, Sakai N: Acid sphigomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells. Exp. Cell Res., 273; 157-168 (2002)

12) Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S: Expression of the NF-κB target gene X-ray-inducible immediate early response factor-1 short enhances TNF-α induced hepatocyte apoptosis by inhibiting Akt activation. J. Immunol., 170; 4053-4060 (2003)

13) Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Iwama T, Sakai N: Ceramide triggers caspase activation during γ-radiation-induced apoptosis of human glioma cells lacking functional p53. Oncol. Rep., 12; 119-123 (2004)

14) Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Yamada J, Iwama T, Banno Y, Shinoda J, Sakai N: p53-Independent ceramide formation in human glioma cells during γ-radiation-induced apoptosis. Cell Death Differ., 11; 853-861 (2004)

15) Sawada M, Nakashima S, Kiyono T, Shinoda J, Naganawa T, Hara S, Iwama T, Sakai N: Molecular mechanisms of TNF-α-induced ceramide formation in human glioma cells. Cell Death Differ., 11; 997-1008 (2004)