Publication List (Dr. Shigeru Nakashima)

Original Papers

1) Imai A, Nakashima S, Nozawa Y: The rapid polyphosphoinositide metabolism may be a triggering event for thrombin-mediated stimulation of human platelets. Biochem. Biophys. Res. Commun., 110; 108-115 (1983)
2) Ishizuka Y, Imai A, Nakashima S, Nozawa Y: Evidence for de novo synthesis of phosphatidylinositol coupled with histamine release in activated rat mast cells. Biochem. Biophys. Res. Commun., 111; 581-587 (1983)
3) Yano K, Nakashima S, Nozawa, Y: Coupling of polyphosphoinositide breakdown with calcium efflux in formyl-methionyl-leucyl-phenylalanine-stimulated rabbit neutrophils. FEBS. Lett., 161; 296-300 (1983)
4)Yawata Y, Sugihara T, Mori M, Nakashima S, Nozawa Y: Lipid analyses and fluidity studies by electron spin resonance of red cell membranes in hereditary high red cell membrane phosphatidylcholine hemolytic anemia. Blood, 64; 1129-1134 (1984)
5) Takahashi M, Imai A, Nakashima S, Nozawa Y: Phospholipid and fatty acid composition of erythrocyte membrane from wild Japanese serow (Capricornis crispuis). Comp. Biochem. Physiol., 77; 369-371 (1984)
6) Yawata Y, Miyashima K, Sugihara T, Murayama N, Hosoda S, Nakashima S, Iida H, Nozawa Y: Self-adaptive modification of red-cell membrane lipids in lecithin-cholesterol acyltransferase deficiency - Lipid analysis and spin labeling. Biochim. Biophys. Acta, 769; 440-448 (1984)
7) Nakashima S, Nagata K, Banno Y, Sakiyama T, Kitagawa T, Miyawaki S, Nozawa Y: A mouse model for Niemann-Pick disease - Phospholipid class and fatty acid composition of various tissues. J. Lipid Res., 25; 219-227 (1984)
8) Imai A, Ishizuka Y, Nakashima S, Nozawa Y: Differential activation of membrane phospholipid turnover by compound 48/80 and ionophore A23187 in rat mast cells. Arch. Biochem. Biophys., 232; 259-268 (1984)
9) Imai A, Hattori H, Takahashi M, Nakashima S, Okano Y, Hattori T, Nozawa Y: Effects of dibutyryl cyclic AMP and forskolin on phospholipid biosynthesis in thrombin-stimulated human platelets. Thromb. Res., 35; 539-546 (1984)
10)Kaiya H, Takeuchi K, Namba M, Imai A, Nakashima S, Nozawa Y: Abnormal phosphatidylinositol-cycle of platelet membrane in schizophrenia- a preliminary study. Folia Pychiat. Neurol. Jpn., 38; 437-444 (1984)
11) Yoshioka T, Inoue H, Kasama T, Seyama Y, Nakashima S, Nozawa Y, Hotta Y: Evidence that arachidonic acid is deficient in phosphatidylinositol of Drosophila heads. J. Biochem., 98; 657-662 (1985)
12) Okano Y, Ishizuka Y, Nakashima S, Tohmatsu T, Takagi H, Nozawa Y: Arachidonic acid release in rat peritoneal mast cells stimulated with antigen, ionophore A23187, and compound 48/80. Biochem. Biophys. Res. Commun., 127; 726-732 (1985)
13) Okano Y, Takagi H, Tohmatsu T, Nakashima S, Kuroda Y, Saito K, Nozawa Y: A wasp venom mastoparan-induced polyphosphoinositide breakdown in rat peritoneal mast cells. FEBS Lett., 188; 363-366 (1985)
14) Yoshioka S, Nakashima S, Okano Y, Hasegawa H, Ichiyama A, Nozawa Y: Phospholipid (diacyl, alkylacyl, alkenylacyl) and fatty acyl chain composition in murine mastocytoma cells. J. Lipid Res., 26; 1134-1141 (1985)
15) Okano Y, Takagi H, Nakashima S, Tohmatsu T, Nozawa Y: Inhibitory action of phorbol myristate acetate on histamine secretion and polyphosphoinositide turnover induced by compound 48/80 in mast cells. Biochem. Biophys. Res. Commun., 132; 110-117 (1985)
16) Nakashima S, Tohmatsu T, Hattori H, Okano Y, Nozawa Y: Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets. Biochem. Biophys. Res. Commun., 135; 1099-1104 (1986)
17) Banno Y, Nakashima S, Nozawa Y: Partial purification of phosphoinositides phospholipase C from human platelet cytosol - Characterization of its three forms. Biochem. Biophys. Res. Commun., 136; 713-721 (1986)
18) Banno Y, Nakashima S, Tohmatsu T, Nozawa Y, Lapetina EG: GTP and GDP will stimulate platelet cytosolic phospholipase C independently of Ca2+. Biochem. Biophys. Res. Commun., 140; 728-734 (1986)
19) Yoshioka S, Nakashima S, Okano Y, Nozawa Y: Arachidonic acid mobilization among phospholipids in murine mastocytoma P-815 cells - Role of ether-linked phospholipids. J. Lipid Res. 27; 939-944 (1986)
20) Nakashima S, Hattori H, Shirato L, Takenaka A, Nozawa Y: Differential sensitivity of arachidonic acid release and 1,2-diacylglycerol formation to pertussis toxin, GTPS and NaF in saponin-permeabilized human platelet - Possible evidence for distinct GTP-binding proteins involving phospholipase C and A2 activation. Biochem. Biophys. Res. Commun., 148; 971-978 (1987)
21) Tohmatsu T, Nakashima S, Hattori H, Suganuma A, Nozawa Y: A role of diacylglycerol kinase in stimulus-secretion coupling of human platelets - Dissociation of serotonin secretion from Ca2+ mobilization. Thromb. Res., 47; 25-35 (1987)
22) Nakashima S, Tohmatsu T, Shirato L, Takenaka A, Nozawa Y: Neomycin is a potent agent for arachidonic acid release in human platelets. Biochem. Biophys. Res. Commun., 146; 820-826 (1987)
23) Nakashima S, Tohmatsu T, Hattori H, Suganuma A, Nozawa Y: Guanine nucleotides stimulate arachidonic acid release by phospholipase A2 in saponin-permeabilized human platelets. J. Biochem., 101; 1055-1058 (1987)
24) Nakashima S, Nagata K, Ueeda K, Nozawa Y: Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils - Evidence for involvement of GTP-binding protein in phospholipase A2 activation. Arch. Biochem. Biophys., 261; 375-383 (1988)
25) Nakashima S, Suganuma A, Matsui A, Hattori H, Sato M, Takenaka A, Nozawa Y: Primary role of calcium ions in arachidonic acid release from rat platelet membranes. Biochem. J., 259; 139-144 (1989)
26) Tohmatsu T, Nakashima S, Nozawa Y: Evidence for Ca2+ mobilizing action of arachidonic acid in human platelets. Biochim. Biophys. Acta, 1012; 97-102 (1989)
27) Nakashima S, Suganuma A, Sato M, Tohmatsu T, Nozawa Y: Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils. J. Immunol., 143; 1295-1302 (1989)
28) Tohmatsu T, Nishida A, Nagao S, Nakashima S, Nozawa Y: Inhibitory action of cyclic AMP in inositol 1,4,5-trisphosphate-induced Ca2+ release in saponin-permeabilized platelets. Biochim. Biophys. Acta, 1013; 190-193 (1989)
29) Nakashima S, Koike T, Nozawa Y: Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses. Mol. Pharmacol., 39; 475-480 (1991)
30) Nakashima S, Suganuma A, Matsui A, Nozawa Y: Thrombin induces a biphasic 1,2-diacylglycerol production in human platelets. Biochem. J., 275; 355-361 (1991)
31) Ishizuka T, Yasuda K, Kajita N, Miura K, Nakashima S, Nagao S, Nozawa Y: Thrombin-induced breakdown of phosphoinositides in platelets from patients with NIDDM. Endocrinol. Jpn., 38; 81-87 (1991)
32) Nakashima S, Fujimiya H, Miyata H, Nozawa Y: Antigen-induced biphasic diacylglycerol formation in RBL-2H3 cells - The late sustained phase due to phosphatidylcholine hydrolysis is dependent on protein kinase C. Biochem. Biophys. Res. Commun., 177; 336-342 (1991)
33) Fujimiya H, Nakashima S, Miyata H, Nozawa Y: Effect of a novel antiallergic drug, pemirolast, on activation of rat peritoneal mast cells - Inhibition of exocytotic response and membrane phospholipid turnover. Int. Arch Allergy Appl. Immunol., 96; 62-67 (1991)
34) Osada S, Nakashima S, Saji S, Nakamura T, Nozawa Y: Hepatocyte growth factor (HGF) mediates the sustained formation of 1,2-diacylglycerol via phosphatidylcholine-phospholipase C in cultured rat hepatocytes. FEBS Lett., 297; 271-274 (1992)
35) Suganuma A, Nakashima S, Okano Y, Nozawa Y: Mass contents of inositol 1,4,5-trisphosphate and 1,2-diacylglycerol in human platelets stimulated with thromboxane analogue and thrombin. Thromb. Haemost., 68; 341-345 (1992)
36) Nakashima S, Chatani Y, Nakamura M, Miyoshi N, Kohno M, Nozawa Y: Tyrosine phosphorylation and activation of mitogen-activated protein kinases by thrombin in human platelets: possible involvement in late arachidonic acid release. Biochem. Biophys. Res. Commun., 198; 497-503 (1994)
37) Kumada T, Nakashima S, Miyata H, Nozawa Y: Potent activation of phospholipase D by phenylarsine oxide in rat basophilic leukemia (RBL-2H3) cells. Biochem. Biophys. Res. Commun., 199; 792-798 (1994)
38) Liu B, Nakashima S, Kanoh H, Takano T, Shimizu T, Nozawa Y: Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. J. Biochem., 116; 882-891 (1994)
39) Suzuki T, Nakashima S, Nozawa Y: Inhibition of phosphatidylinositol 4-phosphate 5-kinase by cyclic AMP in human platelets. Platelets, 5; 258-265 (1994)
40) Suzuki T, Nakashima S, Nozawa Y: Regulation of phosphatidylinositol 4-phosphate 5-kinase by protein kinase C in human platelet membranes. Platelets, 5; 336-342 (1994)
41) Fujimiya H, Nakashima S, Kumada T, Nakamura Y, Miyata H, Nozawa Y: An antiallergic drug, pemirolast potassium, inhibits inositol 1,4,5-trisphosphate production and Ca2+ mobilization in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells. Jpn. J. Allergol., 43; 142-151 (1994)
42) Alam S, Banno Y, Nakashima S, Nozawa Y: Defective phospholipase D activation in Ki-ras-transformed NIH3T3 cells: Evidence for downstream of PLC-1 in PDGF-mediated signal transduction. Biochem. Biophys. Res. Commun., 207; 460-466 (1995)
43) Nakamura Y, Nakashima S, Fujimiya H, Kumada T, Kato Y, Miyata H, Nozawa Y: Effects of an antiallergic drug, pemirolast potassium on tyrosine phosphorylation and MAP kinase activation in antigen-stimulated rat basophilic leukemia (RBL2H3) cells. Jpn. J. Allergol., 44; 34-44 (1995)
44) Banno Y, Nakashima S, Hachiya T, Nozawa Y: Endogenous cleavage of phospholipase C-3 by agonist-induced activation of calpain in human platelets. J. Biol. Chem., 270; 4318-4324 (1995)
45) Ohguchi K, Banno Y, Nakashima S, Nozawa Y: Activation of membrane-bound phospholipase D by protein kinase C in HL60 cells: Synergistic action of a small GTP-binding protein RhoA. Biochem. Biophys. Res. Commun., 211; 306-311 (1995)
46) Nakashima S, Banno Y, Watanabe T, Nakamura Y, Mizutani T, Sakai H, Zhao Y, Sugimoto Y, Nozawa Y.: Depletion and site-directed mutagenesis of EF-hand domain of phospholipase-C1: Effects of its activity. Biochem. Biophys. Res. Commun., 211; 364-369 (1995)
47) Mirbod F, Nakashima S, Mori S, Kitajima Y, Nozawa Y: Phospholipid biosynthesis in growing and non-growing conditions in Candida albicans. Jpn. J. Med. Mycol., 36, 53-59 (1995)
48) Adachi T, Nakashima S, Saji S, Nakamura T, Nozawa Y: Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation. Hepatology, 21; 1668-1674 (1995)
49) Mirbod F, Banno Y, Ghannoum MA, Ibrahim AS, Nakashima S, Kitajima Y, Cole GT, Nozawa Y: Purification and characterization of lysophospholipase-transacylase (h-LPTA) from a highly virulent strain of Candida albicans. Biochim. Biophys. Acta, 1257; 181-188 (1995)
50) Liu B, Nakashima S, Takano T, Shimizu T, Nozawa Y: Implication of protein kinase C in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. Biochem. Biophys. Res. Commun., 214; 418-423 (1995)
51) Kumada T, Nakashima S, Nakamura Y, Miyata H, Nozawa Y: Antigen-mediated phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells : possible involvement of calcium/ calmodulin. Biochim. Biophys. Acta., 1258; 107-114 (1995)
52) Yoshimi N, Ino N, Suzui M, Tanaka T, Nakashima S, Nakamura M, Nozawa Y, Mori H: The mRNA overexpression of inflammatory enzymes, phospholipase A2, cyclooxygenase, in the large bowel mucosa and neoplasms of F344 rats treated with naturally occurring carcinogen, 1-hydroxy-anthraquinone. Cancer Lett., 97; 75-82 (1995)
53) Nakashima S, Mizutani T, Nakamura Y, Takemura SO, Nakamura M, Miyata H, Katagiri Y, Nozawa Y: Effects of selective phosphodiesterase type IV inhibitor, rolipram, on signal transducing phospholipases in neutrophil: Inhibition of phospholipases A2, D but not C. Comp. Biochem. Physiol., 112C; 137-143 (1995)
54) Ohguchi K, Banno Y, Nakashima S, Nozawa Y: Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. J. Biol. Chem., 271; 4366-4372 (1996)
55) Nakamura Y, Nakashima S, Ojio K, Banno Y, Miyata H, Nozawa Y: C2-ceramide inhibits IgE-mediate phospholipase D but not C activation in rat basophilic leukemia (RBL-2H3) cells. J. Immunol., 156; 256-262 (1996)
56) Nakashima S, Zhao Y, Nozawa Y: Molecular cloning of 9 fatty acid desaturase from protozoan Tetrahymena thermophila and its mRNA expression during thermal membrane adaptation. Biochem. J., 317; 29-34 (1996)
57) Adachi T, Nakashima S, Saji S, Nakamura T, Nozawa Y: Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: Involvement of protein tyrosine kinase and protein kinase C. Hepatology, 23; 1244-1253 (1996)
58) Sakai H, Nakashima S, Yoshimura S, Nakatani K, Shinoda J, Sakai N, Yamada H, Nozawa Y: Suppressed expression of CD44 variant isoforms during human glioma A172 cell differentiation induced by cyclic AMP. Neurosci. Lett., 210; 189-192 (1996)
59) Ojio K, Banno Y, Nakashima S, Kato N, Watanabe K, Lyerly DM, Miyata H, Nozawa Y: Effect of Clostridium difficile toxin B on IgE receptor-mediated signal transduction in rat basophilic leukemia cells: inhibition of phospholipase D activation. Biochem. Biophys. Res. Commun., 224; 591-596 (1996)
60) Banno Y, Nakashima S, Ohsawa M, Nozawa Y: Differential translocation of phospholipase C isozymes to integrin-mediated cytoskeletal complexes in thrombin-stimulated human platelets. J. Biol. Chem., 271; 14989-14994 (1996)
61) Banno Y, Ito Y, Ojio K, Kanoh H, Nakashima S, Nozawa Y: Membrane-associated phospholipase D activity in neural cell line PC12. J. Lipid Mediators and Cell Signaling, 14; 237-243 (1996)
62) Nakamura Y, Nakashima S, Kumada T, Ojio K, Miyata H, Nozawa Y: Brefeldin A inhibits antigen- or calcium ionophore-stimulated but not PMA-induced phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells. Immunobiology, 195; 231-242 (1996)
63) Liu B, Nakashima S, Ito S, Nozawa Y: PLD activation in Chinese hamster ovary (CHO) cells transfected with PGF2 receptor cDNA. Prostaglandins, 51; 233-248 (1996)
64) Kumada T, Nakashima S, Nakamura Y, Miyata H, Nozawa Y: Phenylarsine oxide (PAO)-mediated activation of phospholipase D in rat basophilic leukemia (RBL-2H3) cells: Possible involvement of calcium and protein kinase C. Immunobiology, 195; 347-359 (1996)
65) Hashii M, Nakashima S, Yokoyama S, Enomoto K, Minabe Y, Nozawa Y, Higashida H: Bradykinin-activated two signal pathways of protein tyrosine phosphorylation and formation of inositol tetrakisphosphates merge at the Ca2+ influx process in ras-transformed NIH3T3 fibroblast cells. Biochem. J., 319; 649-656 (1996)
66) Yoshimura S, Nakashima S, Ohguchi K, Sakai H, Shinoda J, Sakai N, Nozawa Y: Differential mRNA expression of phospholipase D (PLD) isozymes during cAMP-induced differentiation in C6 glioma cells. Biochem. Biophys. Res. Commun., 225; 494-499 (1996)
67) Adachi T, Nakashima S, Saji S, Nakamura T, Nozawa Y: Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes: Implication in the expression of c-jun and c-fos. Hepatology, 24; 1274-1281 (1996)
68) Ohguchi K, Banno Y, Nakashima S, Kato N, Watanabe K, Lyerly DM, Nozawa Y: Effect of Clostridium difficile Toxin A and Toxin B on phospholipase D activation in human promyelocytic leukemia HL60 cells. Infect. Immun., 64; 4433-4437 (1996)
69) Nakashima S, Iwasaki Y, Mizutani T, Ohguchi K, Sakai H, Nagata K, Kitajima Y, Nozawa Y: Differential expression of protein kinase C isozymes and small GTP-binding proteins during HL-60 cells differentiation by retinoic acid and cyclic AMP: Relation with phospholipase D (PLD) activation. Immunobiology, 195; 231-242 (1996)
70) Alam S, Nakashima S, Deyashiki Y, Banno Y, Hara A, Nozawa Y: Molecular cloning of a gene encoding acid -glucosidase from Tetrahymena pyriformis. J. Euk. Microbiol., 43; 259-303 (1996)
71) Mirbod F, Nakashima S, Kitajima Y, Ghannoum MA, Cannon RD, Nozawa Y: Molecular cloning of a gene encoding translation initiation factor (TIF) from Candida albicans. J. Med. Vet. Mycol., 34; 393-401 (1996)
72) Zhao Y, Nakashima S, Nozawa Y: Molecular cloning of 9 fatty acid desaturase and growth associated changes in its mRNA expression in Tetrahymena pyriformis. Eur J. Prositol., 32; 537-544 (1996)
73) Yoshimura S, Sakai H, Nakashima S, Nozawa Y, Shinoda J, Sakai N, Yamada H: Differential expression of rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation. Mol. Brain Res., 45; 90-98 (1997)
74) Ito Y, Nakashima S, Kanoh H, Nozawa Y: Implication of Ca2+-dependent protein tyrosine phosphorylation in carbachol-induced phospholipase D activation in rat pheochromocytoma PC12 cells. J. Neurochem., 68; 419-425 (1997)
75) Ohguchi K, Nakashima S, Tan Z, Banno Y, Dohi S, Nozawa Y: Enhancement of phospholipase D activity during differentiation in human promyelocytic HL60 cells: Involvement of RhoA translocation to membranes. J. Biol. Chem., 272; 1990-1996 (1997)
76) Hammond SM, Jenco JM, Nakashima S, Cadwallander K, Gu Q, Cook S, Nozawa Y, Prestwich GD, Frohman MA, Morris AJ: Characterization of two alternatively spliced forms of phospholipase D1. J. Biol. Chem., 272; 3860-3868 (1997)
77) Yoshimura Y, Sakai H, Ohguchi K, Nakashima S, Banno Y, Nishimura Y, Sakai N, Nozawa, Y: Changes in the activity and mRNA levels of phospholipase D during ceramide-induced apoptosis in rat C6 glial cells. J. Neurochem., 69; 713-720 (1997)
78) Adachi T, Nakashima S, Nakamura T, Saji S, Nozawa Y: Possible involvement of pertussis toxin-sensitive G protein in hepatocyte growth factor (HGF)-induced signal transduction in cultured rat hepatocytes. Hepatology, 26; 295-300 (1997)
79) Ito Y, Nakashima S, Nozawa, Y.: Hydrogen peroxide-induced phospholipase D activation in rat pheochromocytoma PC12 cells: Possible involvement of Ca2+-dependent protein tyrosine kinase. J. Neurochem., 69; 729-736 (1997)
80) Nakamura M, Nakashima S, Katagiri Y, Nozawa Y: Effect of wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) on N-formyl-methionyl-phenylalanine-induced phospholipase D activation in differentiated HL60 cells. Biochem. Pharmacol., 53; 1929-1936 (1997)
81) Kimura M, Hattori T, Matsuda Y, Yoshioka T, Sumi N, Umeda Y, Nakashima S, Okano Y: cDNA cloning, characterization, and chromosomal mapping of UBE2E/UbcH8, a human novel ubiquitin-conjugating enzyme. Cytogent. Cell Genet., 78; 107-111 (1997)
82) Liu B, Nakashima S, Adachi T, Ito Y, Takano T, Shimizu T, Nozawa Y: Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing PAF receptor lacking cytoplasmic carboxy-terminal tail. Biochem. J., 327; 239-244 (1997)
83) Sakai H, Nakashima S, Yoshimura S, Nishimura Y, Sakai N, Nozawa Y: Identification of differentially expressed mRNAs during rat C6 glioma cell differentiation by mRNA fingerprinting using arbitrarily primed PCR (RAP). Neurosci. Lett., 229; 93-96 (1997)
84) Kovacs P, Nakashima S, Nozawa Y, Casba G: Phospholipase D activity in the Tetrahymena pyriformis GL. Cell Biochem. Funct., 15; 53-60 (1997)
85) Mirbod F, Nakashima S, Kitajima Y, Nozawa Y: Molecular cloning of a Rho family, CDC42Ca gene from Candida albicans and its mRNA expression changes during morphogenesis. J. Med. Vet. Mycol., 35; 173-179 (1997)
86) Zhao Y, Nakashima S, Andoh M, Nozawa Y: Cloning and sequencing of a cDNA encoding glyceraldehyde-3-phosphate dehydrogenase from Tetrahymena thermophila: Growth-associated changes in its mRNA expression. J. Euk. Microbiol., 44, 434-437 (1997)
87) Nakashima S, Matsuda Y, Akao Y, Yoshimura S, Sakai H, Hayakawa K, Andoh M, Nozawa Y: Molecular cloning and chromosome mapping of rat phospholipase D genes, Pld1a, Pld1b and Pld2. Cytogenet. Cell Genet., 79; 109-113 (1997)
88) Sakai H, Nakashima S, Nakatani K, Yoshimura S, Nishimura Y, Sakai N, Nozawa Y: Messenger RNA fingerprinting analysis using arbitrarily primed PCR (RAP) of genes expressed during rat C6 glioma cell differentiation. Brain Tumor Pathol., 14, 119-123 (1997)
89) Nakashima S, Ohguchi K, Frohman MA, Nozawa Y: Increased expression of phospholipase D (PLD) isozymes during granulocytic differentiation of HL60 cells. Biochim. Biophys. Acta, 1389; 173-177 (1998)
90) Sakai H, Nakashima S, Yoshimura S, Nishimura Y, Sakai N, Nozawa Y: Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation. Gene, 209; 87-94 (1998)
91) Hayakawa K, Banno Y, Nakashima S, Ojio K, Ito Y, Nakamura Y, Miyata H, Nozawa Y: Decreased phospholipase D activities in ceramide-induced apoptosis of RBL-2H3 mast cells. Biomed. Res., 19, 159-170 (1998)
92) Yoshimura S, Banno Y, Nakashima S, Takenaka K, Sakai H, Nishimura Y, Sakai N, Shimizu S, Eguchi Y, Tsujimoto Y, Nozawa Y: Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death: Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J. Biol. Chem., 268; 6921-6927 (1998)
93) Nakamura M, Nakashima S, Katagiri Y, Nozawa Y: Involvement of tyrosine phosphorylation in inhibition of fMLP-induced PLD activation by N-acetyl-L-cysteine in differentiated HL60 cells. J. Leukocyte Biol., 63; 781-789 (1998)
94) Kanoh H, Nakashima S, Zhao Y, Sugiyama Y, Kitajima Y, Nozawa Y: Molecular cloning of a gene encoding phospholipase D from the pathogenic and dimorphic fungus, Candida albicans. Biochim. Biophys. Acta, 1398; 359-364 (1998)
95) Leidich SD, Ibrahim AS, Fu Y, Koul A, Jessup C, Vitullo J, Fonzi W, Mirbod F, Nakashima S, Nozawa Y, Ghannoum MA: Cloning and disruption of a caPLB1 a phospholipase B gene involved in the pathogenicity of Candida albicans. J. Biol. Chem., 273; 26078-26086 (1998)
96) Mizutani T, Nakashima S, Nozawa Y: Changes in the expression of protein kinase C (PKC), phospholipases C (PLC) and D (PLD) isoforms in spleen, brain and kidney of the aged rat: RT-PCR and Western blot analysis. Mech. Ageing Develop., 105; 151-172 (1998)
97) Wang S, Nakashima S, Sakai H, Fujiu K, Numara O, Nozawa Y: Molecular cloning and cell cycle-dependent expression of a novel NIMA (never-in mitosis in Aspergillus nidulans)-related protein kinase (TpNrk) in Tetrahymena cells. Biochem. J., 334; 197-203 (1998)
98) Okamoto H, Osawa H, Nakashima S, Takahashi T, Kasemura T, Nozawa Y: Studies on blood compatibility of terpolymers composed of methylmethacrylate methoxypolyethyleneglycol methacrylate and dimethylsiloxane methacrylate. J. Biomater. Sci. Polymer Edn., 9; 943-959 (1998)
99) Ito Y, Nakashima S, Nozawa Y: Possible involvement of mitogen-activated protein kinase in phospholipase D activation induced by H2O2, but not by carbachol in rat pheochromocytoma PC12 cells. J. Neurochem., 71; 2278-2285 (1998)
100) Kasai T, Ohguchi K, Nakashima S, Ito Y, Naganawa T, Kondo N, Nozawa Y: Increased activity of oleate-dependent type phospholipase D during actinomycin D-induced apoptosis in Jurkat T cells. J. Immunol., 161; 6469-6474 (1998)
101) Sugiyama Y, Nakashima S, Mirbod F, Kanoh H, Kitajima Y, Ghannoum MA, Nozawa Y: Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans. J. Med. Mycol., 37; 61-67 (1999)
102) Takanaka K, Sakai H, Yamakawa H, Itoh T, Murase S, Yamakawa H, Okumura A, Nishimura Y, Andoh T, Nakashima S, Nozawa Y, Sakai, N: Analysis for phospholipase C gene in patients with subarachnoid hemorrhage due to ruptured intracranial saccular aneurysm. Neurol. Res., 21; 368-372 (1999)
103) Sugiyama Y, Nakashima S, Mirbod F, Kanoh H, Kitajima Y, Ghannoum MA, Nozawa Y: Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans., Med. Mycol., 37; 61-67 (1999)
104) Nakashima S, Wang S, Hisamoto N, Sakai H, Andoh M, Matsumoto K, Nozawa Y: Molecular cloning and expression of a stress-responsive mitogen-activated protein kinase-related kinase from Tetrahymena cells. J. Biol. Chem., 274; 9976-9983 (1999)
105) Saji S, Nakashima S, Toi M, Hayashi S, Saji S Nozawa Y: Overexpression of MDM2 in MCF-7 promotes both growth advantage and p53 accumulation in response to estradiol. Jap. J. Cancer Res., 90; 210-218 (1999)
106) Takenaka K, Sakai H, Yamakawa H, Yoshimura S, Yamakawa H, Nakashima S, Nozawa Y, Sakai N: Polymorphism of the endoflin gene in patients with intracranial saccular sneurysm. J. Neurosurg., 90; 935-938 (1999)
107) Hayakawa K, Nakashima S, Ito Y, Mizuta K, Miyata H, Nozawa Y: Increased expression of phospholipase D1 mRNA during cAMP- or NGF-induced differentiation in PC12 cells. Neurosci. Lett., 265; 127-130 (1999)
108) Yoshimura S, Banno Y, Nakashima S, Hayashi K, Yamakawa H, Sawada M, Sakai N, Nozawa Y: Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic neuronal cell death. J. Neurochem., 73; 675-683 (1999)
109) Ohguchi K, Nakashima S, Nozawa Y: Phospholipase D development during differentiation of HL60 cells. Biochim. Biophys. Acta, 1439; 215-228 (1999)
110) Wang S, Nakashima S, Numata O, Fujiu K, Nozawa Y: Molecular cloning and cell-cycle-dependent expression of the acetyl-CoA synthetase gene in Tetrahymena cells. Biochem. J., 343; 479-485 (1999)
111) Banno Y, Fujita H, Ono Y, Nakashima S, Ito Y, Kuzumaki N Nozawa Y: Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin. J. Biol. Chem., 274; 27385-27391 (1999)
112) Tan Z, Ohguchi K, Banno Y, Nakashima S, Ono Y, Dohi S, Nozawa, Y: The effects of local anesthetics on phospholipase D activity in differentiated human promyelocytic leukemic HL60 cells. Biochem. Pharmacol., 58; 1881-1889 (1999)
113) Tan Z, Dohi S, Ohguchi K, Nakashima S, Nozawa Y: Local anethetics inhibit muscarinic receptor-mediated activation of extracellular signal-regulated kinases (ERKs) in rat pheochromocytoma PC12 cells. Anethesiology, 91; 1014-1024 (1999)
114) Nagaki M, Sugiyama A, Osawa Y, Naiki T, Nakashima S, Nozawa Y, Moriwaki H: Lethal hepatic apoptosis mediated by tumor necrosis factor receptor, unlike Fas-mediated apoptosis, requires hepatocyte sensitization in mice: J. Hepatol., 41; 997-1005 (1999)
115) Kumada H, Ito Y, Nakashima S, Fujiwara H, Nozawa Y: Hydrogen peroxide-induced phospholipase D activation in human vascular smooth muscle cells. Biomed. Res., 20; 87-98 (1999)
116) Sawada M, Nakashima S, Banno Y, Yamakawa H, Takenaka K, Shinoda J, Nishimura Y, Sakai N, Nozawa Y: Influence of Bax or Bcl-2 overexpression on the ceramide-dependnet apoptotic pathway in glioma cells. Oncogene 19, 3508-3520 (2000)
117) Hamaya Y, Takeda T, Dohi S, Nakashima S, Nozawa Y: The effect of pentobarbital, isoflurane, and propofol on immediate-early gene expression in the vital organs of the rat. Anesth. Analg., 90; 1177-1183 (2000)
118) Sawada M, Nakashima S, Banno Y, Yamakawa H, Hayashi K, Takenaka K, Nishimura Y, Sakai N, Nozawa Y: Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apotosis in C6 glioma cells. Cell Death Differ., 7; 761-772 (2000)
119) Yamakawa H, Ito Y, Naganawa T, Banno Y, Nakashima S, Yoshimura S, Sawada M, Nishimura Y, Nozawa Y, Sakai N: Activation of caspase-9 and -3 during H2O2-induced apoptosis of PC12 cells independnent of ceramide formation. Neurol. Res., 22; 556-564 (2000)
120) Yamakawa H, Banno Y, Nakashima S, Sawada M, Yamada J, Yoshimura S, Nishimura Y, Nozawa Y, Sakai N: Increased phospholipase D2 activity during hypoxia-induced death of PC12 cells: its possible anti-apoptotic role. NeuroReport, 11; 3647-3650 (2000)
121) Nagaki M, Naiki T, Brenner DA, Osawa Y, Imose M, Hayashi H, Banno Y, Nakashima S, Nozawa Y, Moriwaki H: Tumor necrosis factor prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not Fas-mediated apoptosis: role of nuclear factor-. Hepatology, 32; 1272-1279 (2000)
122) Watanabe A, Nakashima S, Adachi T, Saji S, Nozawa Y: Changes in the expression of lipid-mediated signal-transducing enzymes in the rat liver after partial hepatectomy. Surg. Today, 30; 622-630 (2000)
123) Sawada M, Nakashima S, Kiyono T, Nakagawa M, Yamada J, Yamakawa H, Banno Y, Shinoda J, Nishimura Y, Nozawa Y, Sakai N: p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells. Oncogene, 20,1368-1378 (2001)
124) Saji S, Okumura N, Eguchi H, Nakashima S, Suzuki A, Toi M, Nozawa Y, Saji S, Hayashi S: MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells. Biochem. Biophys. Res. Commun., 281, 259-265 (2001)
125) Yamakawa H, Banno Y, Nakashima S, Yoshimura S, Sawada M, Nishimura Y, Nozawa Y, Sakai N: Crucial role of calpain in hypoxic PC12 cell death: Caipain, but nnot caspases, mediates degradation of cytoskeletal proteins and protein kinase C-and -. Neurol. Res., 23; 522-530 (2001)
126) Noda S, Yoshimura S, Sawada M, Nakagawa T, Iwama T, Nakashima S, Sakai N: Role of ceramide during cisplatin-induced apoptosis in C6 cells. J. NeuroOncol., 52; 11-21 (2001)
127) Osawa Y, Nagaki M, Banno Y, Yamada Y, Imose M, Nozawa Y, Moriwaki H, Nakashima S: Possible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor-a-induced hepatocyte apoptosis. J. Cell. Physiol., 187; 374-385 (2001)
128) Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S, Moriwaki H: TNF--Induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J. Immunol., 167; 173-180 (2001)
129) Banno Y, Wang S, Ito Y, Izumi T, Nakashima S, Shimizu T, Nozawa Y: Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells. NeuroReport, 12; 2271-2275 (2001)
130) Osawa Y, Banno Y, Nagaki M, Nozawa Y, Moriwaki H, Nakashima S: Caspase activation during hepatocyte apoptosis induced by tumor necrosis factor- in galactosamine-sensitized mice. Liver, 21; 309-319 (2001)
131) Osawa Y, Nagaki M, Banno Y, Nozawa Y, Moriwaki H, Nakashima S: Sphingosine kinase regulates hepatoma cell differntiation: roles of hepatocyte nuclear factor and retinoid receptor. Biochem. Biophys. Res. Commun., 286; 673-677 (2001)
132) Banno Y, Takuwa Y, Akao Y, Okamoto H, Osawa Y, Naganawa T, Nakashima S, Suh P-G, Nozawa Y: Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. J. Biol. Chem., 276; 35622-35628 (2001)
133) Oishi K, Takahashi M, Mukai H, Banno Y, Nakashima S, Kanaho Y, Nozawa Y, Ono Y: PKN regulates phospholipase D1 through direct interaction. J. Biol. Chem., 276; 18096-18101 (2001)
134) Sawada M, Nakashima S, Kiyono T, Yamada J, Hara S, Nakagawa M, Shinoda J, Sakai N: Acid sphigomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells. Exp. Cell Res., 273; 157-168 (2002)
135) Okumura N, Saji S, Eguchi H, Nakashima S, Saji S, Hayashi S: Distinct promoter usage of mdm2 gene in human breast cancer. Oncol. Rep., 9; 557-563 (2002)
136) Nakagawa M, Nakashima S, Banno Y, Hara S, Yamada J, Sawada M, Yano H, Yoshimura S, Shinoda J, and Sakai N: Increased expression and secretion of the protein homologous to complement C1s precursor during cyclic AMP-induced differentiation in rat C6 glioma cells. Mol. Brain Res., 106; 12-21 (2002)
137) Okumura N, Saji S, Eguchi H, Hayashi S, Saji S, Nakashima S: Estradiol stabilizes p53 protein in breast cancer cell Line, MCF-7. Jpn. J. Cancer. Res., 93; 867-873 (2002)
138) Osawa Y, Nagaki M, Banno Y, Brenner DA, Asano T, Nozawa Y, Moriwaki H, and Nakashima S: TNF--induced IL-8 production via NF-B and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Infect. Immun., 70; 6294-6301 (2002)
139) Yamada J, Yoshimura S, Yamakawa H, Sawada M, Nakagawa M, Hara S, Kaku Y, Iwama T, Naganawa T, Banno Y, Nakashima S, Sakai, N: Cell permeable ROS scavengers, tiron and tempol, rescue PC12 cell death by pyrogallol or hypoxia/reoxygenation. Neurosci. Res., 45; 1-8 (2003)
140) Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S: Expression of the NF-B target gene X-ray-inducible immediate early response factor-1 short enhances TNF- induced hepatocyte apoptosis by inhibiting Akt activation. J. Immunol., 170; 4053-4060 (2003)
141) Aoki K, Ogawa T, Ito Y, Nakashima S: Cisplatin activates survival signals in UM-SCC-23 squamous cell carcinoma and these signal pathways are amplified in cisplatin-resistant squamous cell carcinoma. Oncol. Rep., 11; 375-379 (2004)
142) Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Iwama T, Sakai N: Ceramide triggers caspase activation during -radiation-induced apoptosis of human glioma cells lacking functional p53. Oncol. Rep., 12; 119-123 (2004)
143) Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Yamada J, Iwama T, Banno Y, Shinoda J, Sakai N: p53-Independent ceramide formation in human glioma cells during -radiation-induced apoptosis. Cell Death Differ., 11; 853-861 (2004)
144) Sawada M, Nakashima S, Kiyono T, Shinoda J, Naganawa T, Hara S, Iwama T, Sakai N: Molecular mechanisms of TNF--induced ceramide formation in human glioma cells. Cell Death Differ., 11; 997-1008 (2004)
145) Tsuchiya Y, Nakashima S, Banno Y, Suzuki Y, Morita H: Effect of high-NaCl or high-KCl diet on hepatic Na+- and K+-receptor sensitivity and NKCC1 expression in rats. Am. J. Physiol., 286; R591-596 (2004)
146) Fushimi K, Nakashima S, Banno Y, Akaike A, Takigawa M, Shimizu K: Implication of prostaglandin E2 in TNF--induced release of m-calapin from HCS-2/8 chondrocytes. Oeteoarthritis Cartilage, 12; 895-903 (2004)

Reviews

1) Nozawa Y, Nakashima S, Nagata K: Phospholipid-mediated signaling in receptor activation of human platelets. Biochim. Biophys. Acta, 1082; 219-238 (1991)

Invited Reviews

1) Nakashima S, Nozawa Y: Possible role of phospholipase D (PLD) in cellular differentiation and apoptosis. Chem. Phys. Lipids (Special Issue: New Developments of Phosphoinositide Signaling), 98; 153-164 (1999)
2) Nakashima S: Protein kinase C (PKC): Regulation and biological function. J. Biochem. (JB minireview series-protein kinase C isotypes and their specific function) 132; 669-675 (2002)

Chapter of Books

1) Imai A, Yano K, Nakashima S, Hattori H, Takahashi M, Okano Y, Nozawa Y: Dynamics phospholipids and calcium in secretory cells. Transmembrane Signaling and Sensation (Oosawa, F., Yoshioka, T. and Hayashi, H., eds.); p3-12, Japan Scientific Societies Press (1984)
2) Okano Y, Nakashima S, Tohmatsu T, Ishizuka Y, Takagi H, Nozawa Y: Stimulation-induced release of arachidonic acid from membrane phospholipid in mast cells. Advance in Prostaglandin, Thromboxane, and Leukotriene Research, vol.15 (Hayaishi, O. and Yamamoto, S., eds.); p119-121, Raven Press (1985)
3) Nozawa Y, Banno Y, Nakashima S, Tohmatsu T, Nagao S, Okano Y: Phosphoinositide turnover coupled with receptor activation in human platelets. Platelet Activation (Yamazaki, H. and Mustard, J.F., eds.); p27-42, Academic Press Japan Inc. (1987)
4) Kaiya H, Tamura T, Namba M, Imai A, Nakashima S, Nozawa Y: Impaired phosphatidylinositol(PI) cycle in platelets from schizophrenic patients. Schizophrenia- An Integrative View (Cauzzullo, C.L., Invernizzi, G. and Bressi, C., eds.); p185-189, Ghedini Editore (1987)
5) Okano Y, Nakashima S, Tohmatsu T, Yamada K, Nagata K, Nozawa Y: Guanine nucleotide-dependent release of arachidonic acid in permeabilized inflammatory cells. Cell Calcium Metabolism (Fiskum, G., ed.); p231-236, Plenum Publishing Corporation (1989)
6) Nozawa Y, Nakashima S, Suganuma A, Sato M, Tohmatsu T: Mechanism for arachidonic acid liberation in PAF-stimulated human polymorphonuclear neutrophils. Leukotriene and Prostanoids in Health and Diseases (Zor, U., Naor, Z. and Danon, A., eds.); p279-286, Karger (1989)
7) Nozawa Y, Nakashima S, Banno Y, Nagata K, Nagao S, Okano Y, Tohmatsu T: Regulation of signal-transducing enzymes, phospholipase C and A2 in receptor activation of human platelets - Possible implication of GTP-binding proteins. Physiology and Pharmacology of Transmembrane Signalling (Segawa, T., Endo, M., Ui, M. and Kurihara, K., eds.); p197-206, Elsevier Science Publishers (1989)
8) Nakashima S, Nozawa Y: Receptor-mediated phospholipase D activation in secretory cells. Proceedings of the 3rd International Conference on Lipid Mediators in Health and Disease.(Zor, U. ed.); p65-69, Freund Publishing House Ltd. (1993)
9) Nakashima S, Banno Y, Nozawa Y: Platelet phospholipase C, D. Handbook of Experimental Pharmacology, "Platelets and their factors" (Bruchhausen, V. and Walter, U., eds); p231-246, Springer-Verlag (1997)
10) Nakashima S, Banno Y, Nozawa Y: Role of signal-transducing phospholipase A2, C and D in platelet activation. Advances in Molecular and Cell Biology Series, "The Platelet" (Lapetina, E.G., ed.); p253-274, JAI Press Inc. (1997)
11) Higashida H, Hashii M, Yokoyama S, Taketo M, Hoshi N, Noda M, Zhong ZG, Shahidullah M, Minabe Y, Nakashima S, Nozawa Y: Bradykinin B2 receptors and signal transduction analyzed in NG 108-15 neuroblastoma x glioma hybrid cells, B2 receptor-transformed CHO cells and ras-transformed NIH3T3 fibroblasts. Progress in Brain Research (Kruger, L., ed.); p215-130, Elsevier Science Publisher B.V. (1997)